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藥理毒理室Pharmacology and Toxicology Department

發布時間:2021-03-02 文章來源: 深圳市藥品檢驗研究院
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  主要負責藥品、生物制品、化妝品的功效(或效價)和安全性評價等監督、注冊和委托檢驗工作;認證認可項目近百項。擁有高級職稱人員6人、博士4人、碩士4人,在毒理評價、體外生物活性測定及新方法研究等方面經驗豐富。配有基質輔助激光解析電離飛行時間質譜、數字式單分子免疫陣列分析平臺、核酸分析系統、自動化高通量胚胎細胞分選系統、小動物高分辨率超聲成像系統、灌流式細胞代謝檢測儀、全自動膜片鉗系統、液質聯用儀、高通量測序儀、透射電鏡等實驗儀器,可開展新藥篩選、藥效學及急性毒性、長期毒性、遺傳毒性、免疫原性、生殖毒性、安全藥理、藥代動力學等安全性評價等研究工作,并且制作功效評價用各種疾病模型,建設有“化妝品動物替代試驗技術重點實驗室”和“遺傳毒性檢測與方法研究重點實驗室”。

  We are mainly engaged in supervision, registration, entrustment inspection of efficacy assessment and safety evaluation studies on drug, biological product and cosmetics. We have the ability to carry out about hundred of testing items passed CMA and CNAS certification. In our department, 6 staffers have obtained senior professional title, 4 with PhD degree and 4 with master degree, all with rich practical experience in toxicological evaluation, bioassay and new method research. We are equipped with many advanced instruments including Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF-MS), Single Molecular Array Analysis Platform , Nucleic Acid Analysis System (MassARRAY? System), Large Particle Analysis & Sorting System, High Resolution Ultrasound Imaging System for Small Animals, Cellasys Delivers System with Metabolism Monitor, Patchliner Automatic Patch-clamp System, Liquid Chromatograph/Mass Spectrometer (LC/MS) , High-throughput Sequencer, Transmission Electron Microscope (TEM), etc. We can carry out new drug screening, pharmacodynamics and safety evaluation research on acute toxicity, chronic toxicity, genetic toxicity, immunogenicity, reproduction toxicity, safety pharmacology, pharmacokinetics, etc., as well as simulate a variety of disease animal models used in the efficacy assessment. We construct the key laboratory of study on animal alternative testing techniques in safety evaluation of cosmetics and the key laboratory of genetoxicity detection and method study.

  部門座右銘        以創新為動力,以質量求發展。

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